Cellular reprogramming – lowering gravity on Waddington's epigenetic landscape
نویسندگان
چکیده
منابع مشابه
Cellular reprogramming--lowering gravity on Waddington's epigenetic landscape.
During development, cell fate is specified precisely through programming by multiple complex elements and processes, including chromatin modifications that result in epigenetic marks. Once determined, cell fate is specified further only through maturation processes, which include differentiation and senescence. However, recent studies have shown that it is possible to influence cell fate throug...
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1Dulbecco Telethon Institute (DTI), IRCCS Fondazione Santa Lucia and European Brain Research Institute, 00143 Rome, Italy 2National Research Council, Institute of Translational Pharmacology, via Fosso del Cavaliere 100, 00133 Rome, Italy 3 Institute of Predictive and Personalized Medicine of Cancer (IMPPC), 08916 Badalona, Spain 4 Sanford-Burnham Institute for Medical Research, La Jolla, CA 920...
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The full-term development of sheep, cows, goats, pigs and mice has been achieved through the transfer of somatic cell nuclei into enucleated oocytes. Despite these successes, mammalian cloning remains an inefficient process, with a preponderance of reconstructed embryos failing at early- to mid-gestation stages of development. The small percentage of conceptuses that survive to term are charact...
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Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24060, USA Center for Complex Network Research, Departments of Physics, Biology, and Computer Science, Northeastern University, Boston, MA 02115, USA. Department of Medicine, Harvard Medical School, and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. National Heart, Lung and Blood Institutes...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2012
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.084822